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# Program: MUSTANG-Lite v0.1: A Multiple structural alignment algorithm
# Authors: A. S. Konagurthu, A. M. Lesk, J. C. Whisstock, and P. J. Stuckey
# Rundate: Sat Jul 23 18:30:05 2005
# Report_file: /mnt/EXTRA_STORAGE/MUSTANG_RESULTS/HOMSTRAD_Datasets/results/trfl.html
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#====================================
# Aligned_structures: 7
# 1: 1a8e.pdb
# 2: 1b1xa.pdb
# 3: 1ce2a.pdb
# 4: 1dot.pdb
# 5: 1dsn.pdb
# 6: 1ovt.pdb
# 7: 1tfd.pdb
#
# Length: 712
# Identity: 109/712 ( 15.3%) (Calculated as the percentage of conserved columns in the alignment.)
# Similarity: 140/712 ( 19.7%) (Calculated as the percentage of semi-conserved columns in the alignment)
# Gaps: 430/712 ( 60.4%) (Calculated as the percentage of columns with atleast one gap.)
#===========================================ALIGNMENT START=========================================
1a8e.pdb 1 --D--KTVRWCAVSEHEATKCQSFRDHMKSVIPSDGPSVACVKKASYLDCIRAIAANEAD 56
1b1xa.pdb 1 A--PRKSVRWCTISPAEAAKCAKFQRNMKKVR---GPSVSCIRKTSSFECIQAIAANKAD 55
1ce2a.pdb 1 A--PRKNVRWCTISQPEWLKCHRWQWRMKKLG---APSITCVRRASVLECIRAITEKKAD 55
1dot.pdb 1 -APPKTTVRWCTISSAEEKKCNSLKDHMQQ-E---RVTLSCVQKATYLDCIKAISNNEAD 55
1dsn.pdb 1 --RR-RSVQWCAVSQPEATKCFQWQRNMRRVR---GPPVSCIKRDSPIQCIQAIAENRAD 54
1ovt.pdb 1 -----SVIRWCTISSPEEKKCNNLRDLTQQ-E---RISLTCVQKATYLDCIKAIANNEAD 51
1tfd.pdb 1 -------VRWCAVNDHEASKCANFRDSMKKVLPEDGPRIICVKKASYLDCIKAIAAHEAD 53
vrWC s E KC m C CI AI AD
1a8e.pdb 57 AVTLDAGLVYDAYLAPNNLKPVVAEFYGSKEDPQTFYYAVAVVKKDSGFQMNQLRGKKSC 116
1b1xa.pdb 56 AVTLDGGLVYEAGLHPYKLRPVAAEVYQTRGKPQTRYYAVAVVKKGSGFQLNQLQGVKSC 115
1ce2a.pdb 56 AVTLDGGMVFEAGRDPYKLRPVAAEIYGTKESPQTHYYAVAVVKKGSNFQLDQLQGRNSC 115
1dot.pdb 56 AISLDGGQVFEAGLAPYKLKPIAAEVYERSGGSTTSYYAVAVVKKGTDFMIKDLRGKTSC 115
1dsn.pdb 55 AVTLSGGFIYEAGLAPYKLRPVAAEVYGTERQPRTHYYAVAVVKKGGSFQLNELQGLKSC 114
1ovt.pdb 52 AISLDGGQAFEAGLAPYKLKPIAAEVYEHTEGSTTSYYAVAVVKKGTEFTVNDLQGKTSC 111
1tfd.pdb 54 AVTLDAGLVHEAGLTPNNLKPVVAEFYGSKENPKTFYYAVALVKKGSNFQLNELQGKKSC 113
A Ld G eAgl P L P AE Y T YYAVAvVKKg F L G SC
1a8e.pdb 117 HTGLGRSAGWNIPIGLLYCDL--PEP---RKPLEKAVANFFSGSCAPCADGTDFPQLCQL 171
1b1xa.pdb 116 HTGLGRSAGWNIPIGTLRPYL--NWTGP-PEPLQKAVANFFSASCVPCADGKQYPNLCRL 172
1ce2a.pdb 116 HTGLGRSAGWNIPMGILRPYL--SWTES-LEPLQGAVAKFFSASCVPCVDRQAYPNLCQL 172
1dot.pdb 116 HTGLGRSAGWNIPIGTLIHREDIEWEGIESGISEQAVAKFFSASCVPGAT--IEQKLCRQ 173
1dsn.pdb 115 HTGLRRTAGWNVPIGTLRPFL--NWTGP-PEPIEAAVARFFSASCVPGADKGQFPNLCRL 171
1ovt.pdb 112 HTGLGRSAGWNIPIGTLLHRGAIEWEGIESGSVEQAVAKFFSASCVPGAT--IEQKLCRQ 169
1tfd.pdb 114 HTGLGRSAGWNIPIGLLYCDL--PEP---RKPLEKAVASFFSGSCVPCAD----Q-LCQL 163
HTGLgRsAGWNiPiG L AVA FFS SCvP a LC
1a8e.pdb 172 C------PGCGCSTLNQYFGYSGAFKCLKDGAGDVAFVKHSTIFENLANKADRDQYELLC 225
1b1xa.pdb 173 CAGTEAD-KCACSSQEPYFGYSGAFKCLENGAGDVAFVKDSTVFENLPDEAERDKYELLC 231
1ce2a.pdb 173 CKGEGEN-QCACSPREPYFGYSGAFKCLQDGAGDVAFVKETTVFENLPEKADRDQYELLC 231
1dot.pdb 174 CKGDAKT-KC-LR-NGPYSGYSGAFQCLKDGKGDVAFVKHTTVQENAPE--EKDEYELLC 228
1dsn.pdb 172 CAGTGEN-KCAFSSQEPYFSYSGAFKCLRDGAGDVAFIRESTVFEDLSDEAERDEYELLC 230
1ovt.pdb 170 CKGDPKT-KC-AR-NAPYSGYSGAFHCLKDGKGDVAFVKHTTVNENAPD--QKDEYELLC 224
1tfd.pdb 164 C------PGCGCSSSQPYFGYSGAFKCLKDGLGDVAFVKQETIFENLPSKDERDQYELLC 217
C C pY gYSGAF CL dG GDVAFvk T En D YELLC
1a8e.pdb 226 LDNTRKPVDEYKDCHLAQVPSHTVVARSMGGKEDLIWELLNQAQEHFGKDKSKEFQLFSS 285
1b1xa.pdb 232 PDNTRKPVDAFKECHLARVPSHAVVARSVDGREDLIWKLLHRAQEEFGRNKSSAFQLFGS 291
1ce2a.pdb 232 LNNTRAPVDAFKECHLAQVPSHAVVARSVDGKEDLIWKLLSKAQEKFGKNKSGSFQLFGS 291
1dot.pdb 229 LDGSRQPVDSYKTCNWARVAAHAVVARDDS-KIDDIWSFLGMQAYSLGVDTTSDFHLFGP 287
1dsn.pdb 231 PDNTRKPVDKFKDCHLARVPSHAVVARSVNGKEDAIWNLLRQAQEKFGKDKSPKFQLFGS 290
1ovt.pdb 225 LDGSRQPVDNYKTCNWARVAAHAVVARDDN-KVEDIWSFLSKAQSDFGVDTKSDFHLFGP 283
1tfd.pdb 218 LDNTRKPVDEYEQCHLARVPSHAVVARSVDGKEDLIWELLNQAQEHFGKDKSGDFQLFSS 277
d R PVD k C A V HaVVAR k d IW L aq fG F LF
1a8e.pdb 286 P-H-------GKDLLFKDSAHGFLKVPPR---MDAKMYLGYEYVTAIRNLREGTC----- 329
1b1xa.pdb 292 TPG-------EQDLLFKDSALGFVRIPSQ---IDSGLYLGANYLTATQNLRETA-AEVAA 340
1ce2a.pdb 292 PPG-------QRDLLFKDSALGFLRIPSK---VDSALYLGSRYLTALKNLRETA-EEVQA 340
1dot.pdb 288 ---PGKKDPVLKDLLFKDSAIMLKRVPEL---MDSQLYLGFEYYSAIQSLRKDQ-LTVGP 340
1dsn.pdb 291 PSG-------QKDLLFKDSAIGFSRVPPRIDS---------------------------- 315
1ovt.pdb 284 ---PGKKDPVLKDLLFKDSAIMLKRVPSL---MDSQLYLGFEYYSAIQSMRKDQ-LTPSP 336
1tfd.pdb 278 P-H-------GKNLLFKDSAYGFFK----------------------------------- 294
dLLFKDSA
1a8e.pdb ------------------------------------------------------------
1b1xa.pdb 341 RRERVVWCAVGPEEERKCKQWSDVSNRKVACASASTTEECIALVLKGEADALNLDGGFIY 400
1ce2a.pdb 341 RRARVVWCAVGPEEQKKCQQWSQQSGQIVTCATASTTDDCIALVLKGEADALSLDGGYIY 400
1dot.pdb 341 RENKIQWCAVGKDEKSKCDRWSVVSNGEVECTILDDNKDCIVKITKGEADAISLDGGFVY 400
1dsn.pdb ------------------------------------------------------------
1ovt.pdb 337 RENRIQWCAVGKDEKSKCDRWSVVSNGDVECTVVDETKDCIIKIMKGEADAVALDGGLVY 396
1tfd.pdb ------------------------------------------------------------
1a8e.pdb ------------------------------------------------------------
1b1xa.pdb 401 VAGKCGLVPVLAENQKSQNSNAPDCV-HRPPEGYLAVAVVRKSDADLTWNSLSGKKSCHT 459
1ce2a.pdb 401 TAGKCGLVPVLAENRKSSKHSSLDCV-LRPTEGYLAVAVVKKANEGLTWNSLKGKKSCHT 459
1dot.pdb 401 TAGVCGLVPVVGESYE-DE--TQCSKDEEQPAYYFAVAVVK-KSSAITWNNLQGKKSCHT 456
1dsn.pdb ------------------------------------------------------------
1ovt.pdb 397 TAGVCGLVPVMAERYD-DE--SQCSKTDERPASYFAVAVAR-KDSNVNWNNLKGKKSCHT 452
1tfd.pdb ------------------------------------------------------------
1a8e.pdb ------------------------------------------------------------
1b1xa.pdb 460 GVGRTAAWNIPMGLLFNQTGSCKFDKFFSQSCAPGADPQSSLCALCVGNN-ENENKCMPN 518
1ce2a.pdb 460 AVDRTAGWNIPMGLIANQTGSCAFDEFFSQSCAPGADPKSRLCALCAGDD-QGLDKCVPN 518
1dot.pdb 457 AVGRTAGWNIPMGLIHNKTGSCDFDDYFSEGCAPGSPPNSRLCKLCQGSGENLLEKCVAS 516
1dsn.pdb ------------------------------------------------------------
1ovt.pdb 453 AVGRTAGWVIPMGLIHNRTGTCNFDEYFSEGCAPGSPPNSRLCQLCQGSGGIPPEKCVAS 512
1tfd.pdb ------------------------------------------------------------
1a8e.pdb ------------------------------------------------------------
1b1xa.pdb 519 SEERYYGYTGAFRCLAEKAGDVAFVKDVTVLQNTDGKNSEPWAKDLKQEDFELLCLDGTR 578
1ce2a.pdb 519 SKEKYYGYTGAFRCLAEDVGDVAFVKNDTVWENTNGESTADWAKNLNREDFRLLCLDGTR 578
1dot.pdb 517 SHEKYYGYTGALRCLVE-QGDVAFIKHSTVGENVSGSNKDDWAKGLTRDDFELLCTNGKR 575
1dsn.pdb ------------------------------------------------------------
1ovt.pdb 513 SHEKYFGYTGALRCLVE-KGDVAFIQHSTVEENTGGKNKADWAKNLQMDDFELLCTDGRR 571
1tfd.pdb ------------------------------------------------------------
1a8e.pdb ------------------------------------------------------------
1b1xa.pdb 579 KPVAEAESCHLARAPNHAVVSQSDRAQHLKKVLFLQQDQFGGNGPDCPGKFCLFKSETKN 638
1ce2a.pdb 579 KPVTEAQSCHLAVAPNHAVVSLSERAAHVEQVLLHQQALFGENGKNCPDKFCLFKSETKN 638
1dot.pdb 576 AKTMDYKTCHLAKVPTHAVVARPEKANKIRELLEGQEKLFGLHGTEKER-FMMFQSQTKD 634
1dsn.pdb ------------------------------------------------------------
1ovt.pdb 572 ANVMDYRECNLAEVPTHAVVVRPEKANKIRDLLERQEKRFGVNGSEKSK-FMMFESQNKD 630
1tfd.pdb ------------------------------------------------------------
1a8e.pdb ----------------------------------------------------
1b1xa.pdb 639 LLFNDNTECLAELQGKTTYEQYLGSEYVTSITNLRRCSSSPLLEACAFLRA- 689
1ce2a.pdb 639 LLFNDNTECLAKLGGRPTYEEYLGTEYVTAIANLKKCSTSPLLEACAFLTR- 689
1dot.pdb 635 LLFKALTKCLVKLRQGITYKEFLGDEYYASVASLNTCNPSDLLQVCTFLEDK 686
1dsn.pdb ----------------------------------------------------
1ovt.pdb 631 LLFKDLTKCLFKVREGTTYKEFLGDKFYTVISSLKTCNPSDILQMCSFLEGK 682
1tfd.pdb ----------------------------------------------------
#=========================================ALIGNMENT END=============================================
#LEGEND:
#
# Colours indicate the chemical nature of the amino acid;
# Red = small hydrophobic including aromatic,{A,F,I,L,M,P,V,W}
# Blue = Acidic,{D,E}
# Magenta = Basic,{K,R} and
# Green = Basic amino acids with hydroxyl groups and/or amine groups {C,G,H,N,Q,S,T,Y}.
#
# The "markup row" below each stretch of the multiple alignment is used to mark completely conserved
# residue (denoted in UPPERCASE) and semi-conserved reside ( denoted in lowercase) in a column of the alignment.
#
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